Revision of Adult Antimicrobial Prescribing guidance
The National Institute for Health and Clinical Excellence (NICE) clinical guidance on prophylaxis against infective endocarditis - March 2008
In March 2008, the National Institute for Health and Clinical Excellence (NICE) published new guidance on prophylaxis against infective endocarditis. The evidence reviewed by NICE in the consultation period that preceeded the publication of the latest guidance failed to show that antibiotic prophylaxis is effective, or that there is an association between episodes of infective endocarditis and interventional procedures.
The new guidance recommends that antibiotic prophylaxis should not be given to any patients with structural cardiac defects undergoing dental interventional procedures.
The full guidance can be downloaded below, and can also be found together with a discussion of the relevant evidence at www.nice.org.uk/CG064.
 CG64 Prophylaxis Against Infective Endocarditis: NICE guidance (Mar 2008)
You may also wish to read the letter from the Department of Health following the issue of the new guidance:
Letter from the CDO regarding updated NICE guidance on prophylaxis for infective endocarditis (Mar 2008)
Update to the FGDP(UK)'s AMPS guidance
Please note that the NICE guidance referred to above updates some parts of the FGDP(UK) publication Adult antimicrobial prescribing in primary dental care for general dental practitioners, specifically information on pages 28 and 32-36.
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